The Dosing and Administration of CYTOGAM Are Straightforward1

CYTOGAM dosing is based on body weight, and administered within 72 hours after transplantation and every 2-4 weeks until 16 weeks after transplantation. 

The maximum recommended total dosage per infusion is 150 mg Ig/kg, administered according to the following schedule: 

  • Patients receive CYTOGAM infusions either in inpatient or outpatient settings 
  • CYTOGAM should be administered through an intravenous line using an administration set that contains an in-line filter and a constant infusion pump. Predilution of CYTOGAM before infusion is not recommended 
  • Infusion should begin within 6 hours after entering the vial and should be completed within 12 hours of entering the vial. Patients should be monitored closely during and after each rate change. If a patient develops a minor side effect, slow the rate immediately or temporarily interrupt the infusion 

Preparing to Administer CYTOGAM1

  • Remove the tab portion of the vial cap and clean the rubber stopper with 70% alcohol or equivalent 
  • DO NOT SHAKE VIAL; AVOID FOAMING 
  • Remove the tab portion of the vial cap and clean the rubber stopper with 70% alcohol or equivalent 
  • DO NOT SHAKE VIAL; AVOID FOAMING 

Initial Dose

For the initial dose, administer intravenously at 15 mg Ig/kg/hr. If no adverse reactions occur after 30 minutes, the rate may be increased to 30 mg Ig/kg/hr. If no adverse reactions occur after a subsequent 30 minutes, the infusion may be increased to 60 mg Ig/kg/hr (volume not to exceed 75 mL/hr). 

Subsequent Doses

For subsequent doses, administer at 15 mg Ig/kg/hr for 15 minutes. If no adverse reactions occur, increase to 30 Ig/kg/hr for 15 minutes. Then increase to a maximum rate of 60 mg Ig/kg/hr (volume not to exceed 75 mL/hr). DO NOT EXCEED THIS RATE OF ADMINISTRATION.

Patients should be monitored closely during and after each rate change. 

CYTOGAM is available in a 50 mL single-dose vial (50 mg/mL). 

  • CYTOGAM should be stored between 2-8°C (36-46°F) and used within 6 hours after the healthcare professional has entered the vial 
  • The vial is provided in a carton with a package insert

CYTOGAM is available in a 50 mL single-dose vial (50 mg/mL). 

  • CYTOGAM should be stored between 2-8°C (36-46°F) and used within 6 hours after the healthcare professional has entered the vial 
  • The vial is provided in a carton with a package insert
NDCComponent
49591-532-51 CYTOGAM in a single-dose vial
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