Dosing & Administration
CYTOGAM® (Cytomegalovirus Immune Globulin Intravenous [Human]) (CMV-IGIV) is administered by slow infusion into a vein, usually every 2 to 4 weeks, with the first dose administered within 3 days of the solid organ transplant.1
The Dosing and Administration of CYTOGAM Are Straightforward1
CYTOGAM dosing is based on body weight, and administered within 72 hours after transplantation and every 2-4 weeks until 16 weeks after transplantation.
The maximum recommended total dosage per infusion is 150 mg Ig/kg, administered according to the following schedule:
| Type of Transplant | |||||
|---|---|---|---|---|---|
Kidney
|
Liver
|
Pancreas
|
Lung
|
Heart
|
|
| Within 72 hours of transplant | 150 mg/kg | ||||
| 2 weeks post-transplant | 100 mg/kg | 150 mg/kg | |||
| 4 weeks post-transplant | |||||
| 6 weeks post-transplant | |||||
| 8 weeks post-transplant | |||||
| 12 weeks post-transplant | 50 mg/kg | 100 mg/kg | |||
| 16 weeks post-transplant | |||||
CYTOGAM Is Infused Intravenously1
- Patients receive CYTOGAM infusions either in inpatient or outpatient settings
- CYTOGAM should be administered through an intravenous line using an administration set that contains an in-line filter and a constant infusion pump. Predilution of CYTOGAM before infusion is not recommended
- Infusion should begin within 6 hours after entering the vial and should be completed within 12 hours of entering the vial. Patients should be monitored closely during and after each rate change. If a patient develops a minor side effect, slow the rate immediately or temporarily interrupt the infusion
Preparing to Administer CYTOGAM1
Initial Dose
For the initial dose, administer intravenously at 15 mg Ig/kg/hr. If no adverse reactions occur after 30 minutes, the rate may be increased to 30 mg Ig/kg/hr. If no adverse reactions occur after a subsequent 30 minutes, the infusion may be increased to 60 mg Ig/kg/hr (volume not to exceed 75 mL/hr).
Subsequent Doses
For subsequent doses, administer at 15 mg Ig/kg/hr for 15 minutes. If no adverse reactions occur, increase to 30 Ig/kg/hr for 15 minutes. Then increase to a maximum rate of 60 mg Ig/kg/hr (volume not to exceed 75 mL/hr). DO NOT EXCEED THIS RATE OF ADMINISTRATION.
Patients should be monitored closely during and after each rate change.
Storage and Handling1
| NDC | Component |
|---|---|
| 49591-532-51 | CYTOGAM in a single-dose vial |
Reference: 1. CYTOGAM [package insert]. Kamada Inc.; September 2022.